Rabbit anti-Human NR2E1/TLX Monoclonal Antibody

The antibody against NR2E1/TLX was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human NR2E1 (Q9Y466) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-13988A

Number

Cat.No	ADA-13988A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	NR2E1/TLX
Target Synonyms	TLL; TLX; XTLL; NR2E1/TLX	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, Mouse brain, SH-SY5Y, U-251MG, U-87MG	Application	ELISA, WB

Cat.No

ADA-13988A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

NR2E1/TLX

Target Synonyms

TLL; TLX; XTLL; NR2E1/TLX

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, Mouse brain, SH-SY5Y, U-251MG, U-87MG

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NR2E1 (Q9Y466).	Target Species	Human
Immunogen Sequence	MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIR	Uniprot ID	Q9Y466

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NR2E1 (Q9Y466).

Target Species

Human

Immunogen Sequence

MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIR

Uniprot ID

Q9Y466

Background Information

Uniprot Id

Q9Y466
Target Species

Human
Target Name

NR2E1
Target Full Name

Nuclear receptor subfamily 2 group E member 1
Target Function

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
Target Subcellular Location

Nucleus.
Target Protein Families

Nuclear hormone receptor family, NR2 subfamily
Target Tissue Specificity

Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
Target Synonyms

TLL; TLX; XTLL; NR2E1/TLX
Target Background

The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human NR2E1/TLX Monoclonal Antibody

Specifications

Immunogen Information

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