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The antibody against OSBP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 508-807 of human OSBP (NP_002547.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against OSBP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 508-807 of human OSBP (NP_002547.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-08794A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OSBP |
| Target Synonyms | OSBP1; OSBP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, NIH/3T3, Rat brain, 293T, BT-474, Mouse brain, Mouse liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 508-807 of human OSBP (NP_002547.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P22059 | Immunogen Sequence |
Uniprot Id
P22059
Target Species
Human
Target Name
OSBP
Target Full Name
Oxysterol-binding protein 1
Target Function
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Target Subcellular Location
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network.
Target Protein Families
OSBP family
Target Tissue Specificity
Widely expressed.
Target Synonyms
OSBP 1; OSBP; OSBP1_HUMAN; Oxysterol binding protein 1; Oxysterol-binding protein 1
Target Background
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase
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