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The antibody against PAK1IP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-392 of human PAK1IP1 (NP_060376.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PAK1IP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-392 of human PAK1IP1 (NP_060376.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07040A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAK1IP1 |
| Target Synonyms | PIP1; MAK11; WDR84; hPIP1; bA421M1.5; PAK1IP1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-392 of human PAK1IP1 (NP_060376.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NWT1 | Immunogen Sequence |
Uniprot Id
Q9NWT1
Target Species
Human
Target Name
PAK1IP1
Target Full Name
p21-activated protein kinase-interacting protein 1
Target Function
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Target Subcellular Location
Nucleus, nucleolus.
Target Tissue Specificity
Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.
Target Synonyms
PAK1IP1; PIP1; WDR84; p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1; PAK1-interacting protein 1; WD repeat-containing protein 84
Target Background
Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus.
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