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The antibody against PCDH15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human PCDH15 (NP_001136235.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against PCDH15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human PCDH15 (NP_001136235.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-01252A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PCDH15 |
| Target Synonyms | USH1F; CDHR15; DFNB23; PCDH15 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, 293T, A-549, Mouse brain, Mouse liver, Mouse spleen, Raji, Rat liver, SH-SY5Y | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human PCDH15 (NP_001136235.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96QU1 | Immunogen Sequence |
Uniprot Id
Q96QU1
Target Species
Human
Target Name
PCDH15
Target Full Name
Protocadherin-15
Target Function
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Target Involvement
Usher syndrome 1F (USH1F); Usher syndrome 1D/F (USH1DF); Deafness, autosomal recessive, 23 (DFNB23)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
Target Tissue Specificity
Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed
Target Synonyms
PCDH15; USH1F; Protocadherin-15
Target Background
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.
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