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The antibody against PDCL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human PDCL (NP_005379.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PDCL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human PDCL (NP_005379.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06085A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDCL |
| Target Synonyms | PhLP; PDCL | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HepG2, OVCAR3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human PDCL (NP_005379.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13371 | Immunogen Sequence |
Uniprot Id
Q13371
Target Species
Human
Target Name
PDCL
Target Full Name
Phosducin-like protein
Target Function
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.; Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.; Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
Target Subcellular Location
Cell projection, cilium.
Target Protein Families
Phosducin family
Target Synonyms
OTTHUMP00000022069; PDCL; PHLOP1; PHLP; PHLP_HUMAN; PhLP1; Phosducin like; Phosducin like protein; Phosducin-like protein; RP11-465F21.2
Target Background
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.
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