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The antibody against PMPCB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PMPCB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06335A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PMPCB |
| Target Synonyms | MAS1; MPPB; P-52; MPP11; MPPP52; Beta-MPP; PMPCB | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, HT-1080, LO2, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O75439 | Immunogen Sequence |
Uniprot Id
O75439
Target Species
Human
Target Name
PMPCB
Target Full Name
Mitochondrial-processing peptidase subunit beta
Target Function
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Peptidase M16 family
Target Research Area
Cancer
Target Synonyms
Beta MPP; Beta-MPP; BetaMPP; Mitochondrial processing peptidase subunit beta; Mitochondrial-processing peptidase subunit beta; MPP11; MPPB; MPPB_HUMAN; MPPP52; P 52; P-52; P52; Peptidase mitichondrial processing beta; PMPCB
Target Background
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.
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