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The antibody against PRRT2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-130 of human PRRT2 (NP_660282.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PRRT2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-130 of human PRRT2 (NP_660282.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04682A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRRT2 |
| Target Synonyms | PKC; EKD1; ICCA; BFIC2; BFIS2; DSPB3; DYT10; FICCA; IFITMD1; PRRT2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-130 of human PRRT2 (NP_660282.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | VPGEGPGHSEAETGPPQVLAGVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATADQGSRLESAA | Uniprot ID | Q7Z6L0 |
Uniprot Id
Q7Z6L0
Target Species
Human
Target Name
PRRT2
Target Full Name
Proline-rich transmembrane protein 2
Target Function
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation.
Target Involvement
Episodic kinesigenic dyskinesia 1 (EKD1); Convulsions, familial infantile, with paroxysmal choreoathetosis (ICCA); Seizures, benign familial infantile, 2 (BFIS2)
Target Subcellular Location
Cell membrane; Single-pass membrane protein. Cell junction, synapse, presynaptic cell membrane; Single-pass membrane protein. Cell junction, synapse. Cell projection, axon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, postsynaptic density membrane. Cell projection, dendritic spine.
Target Protein Families
CD225/Dispanin family
Target Synonyms
PRRT2; Proline-rich transmembrane protein 2; Dispanin subfamily B member 3; DSPB3
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