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The antibody against RAB3IP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human RAB3IP (NP_071901.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RAB3IP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human RAB3IP (NP_071901.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01786A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RAB3IP |
| Target Synonyms | RABIN3; RABIN8; RAB3IP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse kidney, Rat brain, 293T, A-549, Mouse brain, Mouse liver, Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human RAB3IP (NP_071901.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MANDPLEGFHEVNLASPTSPDLLGVYESGTQEQTTSPSVIYRPHPSALSSVPIQANALDVSELPTQPVYSSPRRLNCAEISSISFHVTDPAPCSTSGVTAGLTKLTTRKDNYNAEREFLQGATITEACDGSDDIFGLSTDSLSRLRSPSV | Uniprot ID | Q96QF0 |
Uniprot Id
Q96QF0
Target Species
Human
Target Name
RAB3IP
Target Full Name
Rab-3A-interacting protein
Target Function
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
Target Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families
SEC2 family
Target Tissue Specificity
Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.
Target Synonyms
Gtpat12; Rab-3A-interacting protein; RAB3A interacting protein ; RAB3A interacting protein (rabin3); RAB3A interacting protein; RAB3A-interacting protein; RAB3I_HUMAN; Rab3ip; Rabin 3; Rabin-3; RABIN3; RABIN3; rat; homolog of; Rabin8; SSX2 interacting protein ; SSX2 interacting protein; SSX2-interacting protein
Target Background
Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in cilium assembly; protein localization to organelle; and protein targeting to membrane. Located in centrosome; cytosol; and nucleus.
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