Rabbit anti-Human RAB8B Polyclonal Antibody

Uniprot Id

Q92930

Target Species

Human

Target Name

RAB8B

Target Full Name

Ras-related protein Rab-8B

Target Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells.

Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Target Protein Families

Small GTPase superfamily, Rab family

Target Synonyms

5930437D16; D330025I23Rik; FLJ38125; GTPase Rab8b; RAB 8b protein; RAB44; Rab8b; RAB8B, member RAS oncogene family ; RAB8B_HUMAN; Ras-related protein Rab-8B

Target Background

RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).