Rabbit anti-Human RBFOX1 Polyclonal Antibody

Uniprot Id

Q9NWB1

Target Species

Human

Target Name

RBFOX1

Target Full Name

RNA binding protein fox-1 homolog 1

Target Function

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Tissue Specificity

Predominantly expressed in muscle and brain.

Target Synonyms

2BP1; A2 BP1; A2BP 1; A2BP; A2BP1; Ataxin 2 binding protein 1; Ataxin-2-binding protein 1; Ataxin2 binding protein 1; FOX 1; Fox-1 homolog A; fox-1-like RNA-binding protein 1; Hexaribonucleotide binding protein 1; Hexaribonucleotide-binding protein 1; HRNBP 1; HRNBP1; RBFOX1; RFOX1_HUMAN; RNA binding protein fox-1 homolog 1; RNA binding protein fox-1 homolog 1, C. elegans, homolog of, 1; RNA binding protein, fox-1 homolog (C. elegans) 1

Target Background

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.