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The antibody against RRAGD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 181-400 of human RRAGD (NP_067067.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against RRAGD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 181-400 of human RRAGD (NP_067067.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-08888A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RRAGD |
| Target Synonyms | RAGD; HOMG7; bA11D8.2.1; RRAGD | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, 22Rv1, HL-60, Mouse skeletal muscle, NCI-H460, SH-SY5Y, SW480 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 181-400 of human RRAGD (NP_067067.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NQL2 | Immunogen Sequence |
Uniprot Id
Q9NQL2
Target Species
Human
Target Name
RRAGD
Target Full Name
Ras-related GTP-binding protein D
Target Function
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.
Target Subcellular Location
Cytoplasm. Nucleus. Lysosome.
Target Protein Families
GTR/RAG GTP-binding protein family
Target Synonyms
bA11D8.2.1; DKFZp761H171; FLJ44176; OTTHUMP00000016853; Rag D; Rag D protein; RagD; RagDRRAGD; Ras related GTP binding D; Ras-related GTP binding protein D; Ras-related GTP-binding protein D; RRAGD; RRAGD_HUMAN
Target Background
RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.
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