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Rabbit anti-Human SLC3A1 Polyclonal Antibody

The antibody against SLC3A1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 416-685 of human SLC3A1 (NP_000332.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-09679A

The antibody against SLC3A1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 416-685 of human SLC3A1 (NP_000332.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

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Specifications


Cat.No ADA-09679A ClonalityPolyclonal
Host SpeciesRabbitTarget NameSLC3A1
Target SynonymsD2H; ATR1; NBAT; RBAT; CSNU1; SLC3A1FormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive Samples293T, BxPC-3, HepG2, HT-29, Mouse liver, PC-12ApplicationELISA, WB, IHC-P

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 416-685 of human SLC3A1 (NP_000332.2).Target SpeciesHuman
Uniprot IDQ07837Immunogen Sequence
Background Information
  • Uniprot Id

    Q07837

  • Target Species

    Human

  • Target Name

    SLC3A1

  • Target Full Name

    Amino acid transporter heavy chain SLC3A1

  • Target Function

    Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.

  • Target Involvement

    Cystinuria (CSNU); Hypotonia-cystinuria syndrome (HCS)

  • Target Subcellular Location

    Membrane; Single-pass type II membrane protein.

  • Target Tissue Specificity

    Expressed in the brush border membrane in the kidney (at protein level). Predominantly expressed in the kidney, small intestine and pancreas. Weakly expressed in liver.

  • Target Synonyms

    D2H; ATR1; NBAT; RBAT; CSNU1; SLC3A1

  • Target Background

    This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

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