Rabbit anti-Human Smad6 Polyclonal Antibody

The antibody against Smad6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 257-496 of human Smad6 (NP_005576.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11504A

Number

Cat.No	ADA-11504A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SMAD6
Target Synonyms	AOVD2; MADH6; MADH7; HsT17432; Smad6	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Rat brain, 22Rv1	Application	ELISA, WB

Cat.No

ADA-11504A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SMAD6

Target Synonyms

AOVD2; MADH6; MADH7; HsT17432; Smad6

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Rat brain, 22Rv1

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 257-496 of human Smad6 (NP_005576.3).	Target Species	Human
Uniprot ID	O43541	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 257-496 of human Smad6 (NP_005576.3).

Target Species

Human

Uniprot ID

O43541

Immunogen Sequence

Background Information

Uniprot Id

O43541
Target Species

Human
Target Name

SMAD6
Target Full Name

Mothers against decapentaplegic homolog 6
Target Function

Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Target Involvement

Aortic valve disease 2 (AOVD2); Craniosynostosis 7 (CRS7)
Target Subcellular Location

Nucleus.
Target Protein Families

Dwarfin/SMAD family
Target Tissue Specificity

Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

hSMAD6; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; Mothers against DPP homolog 6; SMAD 6; SMAD family member 6; SMAD mothers against DPP homolog 6; Smad6; SMAD6_HUMAN
Target Background

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.

Rabbit anti-Human Smad6 Polyclonal Antibody

Specifications

Immunogen Information

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