Rabbit anti-Human SOX4 Polyclonal Antibody

Uniprot Id

Q06945

Target Species

Human

Target Name

SOX4

Target Full Name

Transcription factor SOX-4

Target Function

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Testis, brain, and heart.

Target Synonyms

CSS10; EVI16; SOX4

Target Background

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.