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The antibody against TAGLN was raised in rabbit using the Recombinant Human Transgelin protein (2-201AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against TAGLN was raised in rabbit using the Recombinant Human Transgelin protein (2-201AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human smooth muscle tissue using TAGLN Antibody at dilution of 1:1002
| Cat.No | ADC-54532A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TAGLN |
| Target Synonyms | TAGLN antibody; SM22 antibody; WS3-10 antibody; Transgelin antibody; 22 kDa actin-binding protein antibody; Protein WS3-10 antibody; Smooth muscle protein 22-alpha antibody; SM22-alpha antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transgelin protein (2-201AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q01995 |
Uniprot Id
Q01995
Target Species
Human
Target Name
TAGLN
Target Full Name
Transgelin
Target Function
Actin cross-linking/gelling protein. Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Calponin family
Target Research Area
Signal Transduction
Target Synonyms
TAGLN; SM22; WS3-10; Transgelin; 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha; SM22-alpha
Target Background
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.
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