Rabbit anti-Human THOC3 Polyclonal Antibody

The antibody against THOC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human THOC3 (NP_115737.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03536A

Number

Cat.No	ADA-03536A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	THOC3
Target Synonyms	THO3; hTREX45; THOC3	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	LO2, Mouse brain	Application	ELISA, WB

Cat.No

ADA-03536A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

THOC3

Target Synonyms

THO3; hTREX45; THOC3

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

LO2, Mouse brain

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human THOC3 (NP_115737.1).	Target Species	Human
Immunogen Sequence	MAVPAAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLT	Uniprot ID	Q96J01

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human THOC3 (NP_115737.1).

Target Species

Human

Immunogen Sequence

MAVPAAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLT

Uniprot ID

Q96J01

Background Information

Uniprot Id

Q96J01
Target Species

Human
Target Name

THOC3
Target Full Name

THO complex subunit 3
Target Function

Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Target Subcellular Location

Nucleus. Nucleus speckle.
Target Synonyms

hTREX45; TEX1 homolog; THO complex subunit 3; Tho3; THOC3; THOC3_HUMAN
Target Background

This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5.

Rabbit anti-Human THOC3 Polyclonal Antibody

Specifications

Immunogen Information

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