Rabbit anti-Human TRPC6 Polyclonal Antibody

The antibody against TRPC6 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 466-565 of human TRPC6 (NP_004612.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-09135A

Number

Cat.No	ADA-09135A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TRPC6
Target Synonyms	TRP6; FSGS2; TRPC6	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, Mouse pancreas	Application	ELISA, WB, IHC-P

Cat.No

ADA-09135A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TRPC6

Target Synonyms

TRP6; FSGS2; TRPC6

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, Mouse pancreas

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 466-565 of human TRPC6 (NP_004612.2).	Target Species	Human
Immunogen Sequence	EGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLK	Uniprot ID	Q9Y210

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 466-565 of human TRPC6 (NP_004612.2).

Target Species

Human

Immunogen Sequence

EGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLK

Uniprot ID

Q9Y210

Background Information

Uniprot Id

Q9Y210
Target Species

Human
Target Name

TRPC6
Target Full Name

Short transient receptor potential channel 6
Target Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Target Involvement

Focal segmental glomerulosclerosis 2 (FSGS2)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein.
Target Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC6 sub-subfamily
Target Tissue Specificity

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
Target Research Area

Neuroscience
Target Synonyms

TRP6; FSGS2; TRPC6
Target Background

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Rabbit anti-Human TRPC6 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human TRPC6 Polyclonal Antibody Now

Related Products