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The antibody against TTL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TTL (NP_714923.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TTL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TTL (NP_714923.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06488A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TTL |
| Target Synonyms | TTL | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse brain, Mouse lung, Rat kidney, SH-SY5Y, SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TTL (NP_714923.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8NG68 | Immunogen Sequence |
Uniprot Id
Q8NG68
Target Species
Human
Target Name
TTL
Target Full Name
Tubulin--tyrosine ligase
Target Function
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Target Protein Families
Tubulin--tyrosine ligase family
Target Synonyms
TTL; Tubulin--tyrosine ligase; TTL; EC 6.3.2.25
Target Background
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).
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