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The antibody against UBR7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 76-425 of human UBR7 (NP_786924.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against UBR7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 76-425 of human UBR7 (NP_786924.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00596A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | UBR7 |
| Target Synonyms | LICAS; C14orf130; UBR7 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Jurkat, Mouse testis, Mouse thymus, Rat thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 76-425 of human UBR7 (NP_786924.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N806 | Immunogen Sequence |
Uniprot Id
Q8N806
Target Species
Human
Target Name
UBR7
Target Full Name
Putative E3 ubiquitin-protein ligase UBR7
Target Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Target Tissue Specificity
Expressed in sperm (at protein level).
Target Synonyms
UBR7; C14orf130; Putative E3 ubiquitin-protein ligase UBR7; EC 2.3.2.27; N-recognin-7; RING-type E3 ubiquitin transferase UBR7
Target Background
This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome.
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