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The antibody against USP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human USP1 (NP_003359.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against USP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human USP1 (NP_003359.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02844A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP1 |
| Target Synonyms | UBP; USP1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HepG2, MCF7, Mouse brain, Mouse spleen, Mouse testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human USP1 (NP_003359.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O94782 | Immunogen Sequence |
Uniprot Id
O94782
Target Species
Human
Target Name
USP1
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 1
Target Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Target Subcellular Location
Nucleus.
Target Protein Families
Peptidase C19 family
Target Synonyms
Deubiquitinating enzyme 1; hUBP; Ubiquitin carboxyl terminal hydrolase 1; Ubiquitin carboxyl-terminal hydrolase 1; Ubiquitin specific peptidase 1; Ubiquitin specific protease 1; Ubiquitin thioesterase 1; Ubiquitin thiolesterase 1; Ubiquitin-specific-processing protease 1; UBP; UBP1_HUMAN; USP 1; Usp1
Target Background
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.
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