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The antibody against USP53 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 886-1073 of human USP53 (NP_061923.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against USP53 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 886-1073 of human USP53 (NP_061923.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05700A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP53 |
| Target Synonyms | PFIC7; USP53 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A-431, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 886-1073 of human USP53 (NP_061923.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MDQCYFENSLSTECIIRSASRSDGCQMPKLFCQNLPPPLPPKKYAITSVPQSEKSESTPDVKLTEVFKATSHLPKHSLSTASEPSLEVSTHMNDERHKETFQVRECFGNTPNCPSSSSTNDFQANSGAIDAFCQPELDSISTCPNETVSLTTYFSVDSCMTDTYRLKYHQRPKLSFPESSGFCNNSLS | Uniprot ID | Q70EK8 |
Uniprot Id
Q70EK8
Target Species
Human
Target Name
USP53
Target Full Name
Inactive ubiquitin carboxyl-terminal hydrolase 53
Target Function
Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions. Has no peptidase activity.
Target Subcellular Location
Cell junction, tight junction.
Target Protein Families
Peptidase C19 family
Target Tissue Specificity
Expressed predominantly in skeletal muscle and heart.
Target Synonyms
USP53; KIAA1350; Inactive ubiquitin carboxyl-terminal hydrolase 53; Inactive ubiquitin-specific peptidase 53
Target Background
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in response to auditory stimulus and sensory perception of sound. Predicted to act upstream of or within action potential and neuron apoptotic process. Predicted to be located in bicellular tight junction. Predicted to be active in cell-cell junction.
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