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The antibody against VLDLR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 833-869 of human VLDLR (NP_003374.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against VLDLR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 833-869 of human VLDLR (NP_003374.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09340A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VLDLR |
| Target Synonyms | CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH; VLDLR | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse lung, Mouse ovary, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 833-869 of human VLDLR (NP_003374.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | DNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTD | Uniprot ID | P98155 |
Uniprot Id
P98155
Target Species
Human
Target Name
VLDLR
Target Full Name
Very low-density lipoprotein receptor
Target Function
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
Target Involvement
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1)
Target Subcellular Location
Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
Target Tissue Specificity
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.
Target Synonyms
FLJ35024; Very low density lipoprotein receptor; Very low-density lipoprotein receptor; VLDL R; VLDL receptor; VLDL-R; VLDLR; VLDLR_HUMAN; VLDLRCH
Target Background
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.
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