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The antibody against ZNF346 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-294 of human ZNF346 (NP_036411.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZNF346 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-294 of human ZNF346 (NP_036411.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02457A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZNF346 |
| Target Synonyms | JAZ; Zfp346; ZNF346 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, A-549, MCF7, Mouse brain, Mouse testis, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-294 of human ZNF346 (NP_036411.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UL40 | Immunogen Sequence |
Uniprot Id
Q9UL40
Target Species
Human
Target Name
ZNF346
Target Full Name
Zinc finger protein 346
Target Function
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins.
Target Subcellular Location
Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
DKFZp547M223; Double stranded RNA binding zinc finger protein; Double stranded RNA binding zinc finger protein JAZ; JAZ; Just another zinc finger protein; Zfp346; Zinc finger protein 346; ZN346_HUMAN; Znf346
Target Background
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants.
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