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The antibody against ZP2 was raised in rabbit using the Recombinant Human Zona pellucida sperm-binding protein 2 protein (440-716aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against ZP2 was raised in rabbit using the Recombinant Human Zona pellucida sperm-binding protein 2 protein (440-716aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-54868A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZP2 |
| Target Synonyms | Zona pellucida sperm-binding protein 2 (Zona pellucida glycoprotein 2) (Zp-2) (Zona pellucida protein A) [Cleaved into: Processed zona pellucida sperm-binding protein 2], ZP2, ZPA | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Zona pellucida sperm-binding protein 2 protein (440-716aa) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q05996 |
Uniprot Id
Q05996
Target Species
Human
Target Name
ZP2
Target Full Name
Zona pellucida sperm-binding protein 2
Target Function
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
Target Subcellular Location
[Processed zona pellucida sperm-binding protein 2]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
Target Protein Families
ZP domain family, ZPA subfamily
Target Tissue Specificity
Expressed in occytes(at protein level).
Target Synonyms
ZPA; Zp-2; OOMD6; OZEMA6; ZP2
Target Background
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants.
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