Rabbit anti-Human ZRANB3 Polyclonal Antibody

Uniprot Id

Q5FWF4

Target Species

Human

Target Name

ZRANB3

Target Full Name

DNA annealing helicase and endonuclease ZRANB3

Target Function

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Target Subcellular Location

Nucleus. Chromosome.

Target Protein Families

SNF2/RAD54 helicase family

Target Synonyms

4933425L19Rik; AH2; Annealing helicase 2; DNA annealing helicase and endonuclease ZRANB3; MGC105033; MGC75012; OTTHUMP00000197449; Zinc finger Ran-binding domain-containing protein 3; Zinc finger; RAN- binding domain containing 3; ZRAB3_HUMAN; Zranb3

Target Background

Enables ATP-dependent DNA/DNA annealing activity; K63-linked polyubiquitin modification-dependent protein binding activity; and endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Located in nuclear replication fork and nucleoplasm.