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The antibody against pum was raised in rabbit using the Recombinant Drosophila melanogaster (Fruit fly) pum protein (1091-1330aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
The antibody against pum was raised in rabbit using the Recombinant Drosophila melanogaster (Fruit fly) pum protein (1091-1330aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
$299.00
Western Blot | Positive WB detected in: recombinant protein | All lanes: pum Antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 30 kDa | Observed band size: 30 kDa
| Cat.No | ADC-55384A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | pum |
| Target Synonyms | Maternal protein pumilio pum CG9755 | Form | Liquid |
| Species Reactivity | Drosophila melanogaster (Fruit fly) | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Affinity-chromatography purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Drosophila melanogaster (Fruit fly) pum protein (1091-1330aa) | Target Species | Drosophila melanogaster (Fruit fly) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P25822 |
Uniprot Id
P25822
Target Species
Drosophila melanogaster
Target Name
PUM
Target Function
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Mediates post-transcriptional silencing of E2f mRNA by binding to its 3'-UTR and promoting miRNA regulation. Required for abdominal development and to support proliferation and self-renewal of germ cells. Pum is the only gene required for nos activity that is not also required for posterior localization of germline determinants. Pum is required during embryogenesis when nos activity apparently moves anteriorly from the posterior pole.
Target Subcellular Location
Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule.
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Advenit post multos Scudilo Scutariorum tribunus velament
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