Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1), Truncated

Uniprot Id

Q9NQ66

Target Species

Human

Target Name

PLCB1

Target Full Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Target Function

Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.

Target Involvement

Epileptic encephalopathy, early infantile, 12 (EIEE12)

Target Subcellular Location

Nucleus membrane. Cytoplasm.

Target Synonyms

1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase beta 1; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta-1; EIEE12; Inositoltrisphosphohydrolase; Monophosphatidylinositol phosphodiesterase; Phosphb; Phosphoinositidase C; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta 1; Phosphoinositide phospholipase C-beta-1; Phospholipase C beta 1 (phosphoinositide-specific); Phospholipase C I; Phospholipase C-beta-1; Phospholipase C-I; PI PLC; PLC 1; PLC beta 1; PLC I; PLC-154; PLC-beta-1; PLC-I; PLC154; Plcb; Plcb1; Plcb1 protein ; PLCB1_HUMAN; PLCbeta1; Triphosphoinositide phosphodiesterase

Target Background

The protein encoded by this gene catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.