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| Cat.No | ACP17397 | Target Name | PLCH1 |
|---|---|---|---|
| Target Synonyms | 1-phosphatidylinositol 4; 1-phosphatidylinositol-4; 1-phosphatidylinositol-4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q4KWH8 |
|---|
Uniprot Id
Q4KWH8
Target Species
Human
Target Name
PLCH1
Target Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Target Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Target Subcellular Location
Cytoplasm. Membrane.
Target Tissue Specificity
Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.
Target Synonyms
1-phosphatidylinositol 4; 1-phosphatidylinositol-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1; 5-bisphosphate phosphodiesterase eta-1; DKFZp434C1372; KIAA1069; MGC117152; Phosphoinositide phospholipase C-eta-1; Phospholipase C-eta-1; Phospholipase C-like protein 3; PLC-eta-1; PLC-L3; PLCeta1; Plch1; PLCH1_HUMAN; PLCL3
Target Background
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) to generate second messengers inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).
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