Recombinant Human 60S ribosomal protein L23a (RPL23A)

Uniprot Id

P62750

Target Species

Human

Target Name

RPL23A

Target Full Name

Large ribosomal subunit protein uL23

Target Function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination.

Target Protein Families

Universal ribosomal protein uL23 family

Target Synonyms

60S ribosomal protein L23A; FLJ27455; L23A; MDA20; Melanoma differentiation-associated gene 20; Ribosomal protein L23a; RL23A_HUMAN; RPL23A

Target Background

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.