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This Human NUDT1 recombinant protein was produced in E.coli, where the gene sequence encoding Human NUDT1 (19-197aa) was expressed with Tag-Free. The purity of this NUDT1 protein was greater than 85% by SDS-PAGE.NUDT1's primary function is to prevent the accumulation of 7,8-dihydro-8-oxoguanine triphosphate (8-oxo-dGTP) in cells. This compound is one of the most common oxidative damages to DNA and can lead to DNA mutations and genomic instability, increasing the risk of cancer and other diseases. NUDT1 hydrolyzes 8-oxo-dGTP, converting it into 8-oxo-dGMP, thereby preventing this oxidative damage from being incorporated into newly synthesized DNA strands. This helps maintain the integrity and stability of DNA. NUDT1 has generated significant interest in cancer research. Some studies have found that the activity of NUDT1 is reduced in certain cancer cells, leading to the accumulation of oxidative damage in DNA, which promotes the development of tumors. Therefore, researchers are investigating whether defects in NUDT1 can be exploited to develop new anti-cancer drugs or treatment approaches.
This Human NUDT1 recombinant protein was produced in E.coli, where the gene sequence encoding Human NUDT1 (19-197aa) was expressed with Tag-Free. The purity of this NUDT1 protein was greater than 85% by SDS-PAGE.NUDT1’s primary function is to prevent the accumulation of 7,8-dihydro-8-oxoguanine triphosphate (8-oxo-dGTP) in cells. This compound is one of the most common oxidative damages to DNA and can lead to DNA mutations and genomic instability, increasing the risk of cancer and other diseases. NUDT1 hydrolyzes 8-oxo-dGTP, converting it into 8-oxo-dGMP, thereby preventing this oxidative damage from being incorporated into newly synthesized DNA strands. This helps maintain the integrity and stability of DNA. NUDT1 has generated significant interest in cancer research. Some studies have found that the activity of NUDT1 is reduced in certain cancer cells, leading to the accumulation of oxidative damage in DNA, which promotes the development of tumors. Therefore, researchers are investigating whether defects in NUDT1 can be exploited to develop new anti-cancer drugs or treatment approaches.
| Cat.No | ACP03591 | Target Name | NUDT1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 19-197aa | Mol Weight | 20.3 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P36639 |
|---|
Uniprot Id
P36639
Target Species
Human
Target Name
NUDT1
Target Full Name
Oxidized purine nucleoside triphosphate hydrolase
Target Function
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Target Subcellular Location
[Isoform p18]: Cytoplasm, cytosol. Mitochondrion matrix. Nucleus.; [Isoform p26]: Mitochondrion matrix.
Target Protein Families
Nudix hydrolase family
Target Tissue Specificity
Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
2-hydroxy-dATP diphosphatase; 7 8 dihydro 8 oxoguanine triphosphatase; 7; 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase; 8 oxo 7 8 dihydroguanosine triphosphatase; 8 oxo dGTPase; 8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; 8ODP_HUMAN; MTH 1; MTH1; MutT human homolog 1; Nucleoside diphosphate linked moiety X motif 1; Nucleoside diphosphate linked moiety X type motif 1; Nucleoside diphosphate-linked moiety X motif 1; Nudix (nucleoside diphosphate linked moiety X) type motif 1; Nudix hydrolase 1; Nudix motif 1; Nudix type motif 1; NUDT 1; Nudt1
Target Background
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
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