Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Uniprot Id

Q9UHI8

Target Species

Human

Target Name

ADAMTS1

Target Full Name

A disintegrin and metalloproteinase with thrombospondin motifs 1

Target Function

Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Synonyms

A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; ADAM-TS1; ADAMTS 1; ADAMTS; ADAMTS-1; Adamts1; ATS1_HUMAN; C3 C5; KIAA1346,; METH 1; METH-1

Target Background

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.