Recombinant Human A-kinase anchor protein 4 (AKAP4)

Uniprot Id

Q5JQC9

Target Species

Human

Target Name

AKAP4

Target Full Name

A-kinase anchor protein 4

Target Function

Major structural component of sperm fibrous sheath. Plays a role in sperm motility.

Target Subcellular Location

Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum.

Target Protein Families

AKAP110 family

Target Tissue Specificity

Testis specific; only expressed in round spermatids.

Target Research Area

Signal Transduction

Target Synonyms

A kinase (PRKA) anchor protein 4; A kinase anchor protein 4; A kinase anchor protein 82 kDa; A-kinase anchor protein 4; A-kinase anchor protein 82 kDa; AKAP 4; AKAP 82; AKAP-4; AKAP4; AKAP4_HUMAN; AKAP82; FSC 1; FSC1; hAKAP 82; hAKAP82; HI; Major sperm fibrous sheath protein; p82; PRKA 4; PRKA4; Protein kinase A anchoring protein 4; Protein kinase A-anchoring protein 4; Testis specific gene HI

Target Background

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.