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| Cat.No | ACP11383 | Target Name | ABI3 |
|---|---|---|---|
| Target Synonyms | ABI3; NESHABI gene family member 3; New molecule including SH3; Nesh | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-366 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9P2A4 |
|---|
Uniprot Id
Q9P2A4
Target Species
Human
Target Name
ABI3
Target Full Name
ABI gene family member 3
Target Function
May inhibit tumor metastasis. In vitro, reduces cell motility.
Target Subcellular Location
Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells.
Target Protein Families
ABI family
Target Tissue Specificity
Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
Target Synonyms
ABI3; NESHABI gene family member 3; New molecule including SH3; Nesh
Target Background
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants.
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