Recombinant Human Acyl-CoA wax alcohol acyltransferase 2 (AWAT2), Truncated

Uniprot Id

Q6E213

Target Species

Human

Target Name

AWAT2

Target Full Name

Acyl-CoA wax alcohol acyltransferase 2

Target Function

Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

Diacylglycerol acyltransferase family

Target Tissue Specificity

Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas.

Target Synonyms

AWAT2; DC4; DGAT2L4; MFAT; WS; Acyl-CoA wax alcohol acyltransferase 2; 11-cis-specific retinyl-ester synthase; 11-cis-RE-synthase; Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Retinol O-fatty-acyltransferase; Diacylglycerol O-acyltransferase 2-like protein 4; Diacylglycerol O-acyltransferase candidate 4; hDC4; Long-chain-alcohol O-fatty-acyltransferase 2; Multifunctional O-acyltransferase; Wax synthase; hWS