Recombinant Human ADAMTS-like protein 4 (ADAMTSL4), Truncated

Uniprot Id

Q6UY14

Target Species

Human

Target Name

ADAMTSL4

Target Full Name

ADAMTS-like protein 4

Target Function

Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.

Target Involvement

Ectopia lentis 2, isolated, autosomal recessive (ECTOL2); Ectopia lentis et pupillae (ECTOLP)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix. Note=Colocalizes with FMN1 microfibrils in the eye ECM.

Target Tissue Specificity

Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lun

Target Synonyms

ADAMTSL4; TSRC1; PP1396; UNQ2803/PRO34012ADAMTS-like protein 4; ADAMTSL-4; Thrombospondin repeat-containing protein 1

Target Background

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.