Recombinant Human ADP-ribose glycohydrolase ARH3(ADPRS)

Cat.No	ACP11713	Target Name	ADPRHL2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-363	Protein Length	Full length
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP11713

Target Name

ADPRHL2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-363

Protein Length

Full length

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NX46

Background Information

Uniprot Id

Q9NX46
Target Species

Human
Target Name

ADPRS
Target Full Name

ADP-ribosylhydrolase ARH3
Target Function

ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
Target Subcellular Location

Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix.
Target Protein Families

ADP-ribosylglycohydrolase family
Target Tissue Specificity

Ubiquitous.
Target Synonyms

[Protein ADP ribosylarginine] hydrolase like protein 2; [Protein ADP-ribosylarginine] hydrolase-like protein 2; ADP ribosylhydrolase 3; ADP ribosylhydrolase like 2; ADP-ribosylhydrolase 3; Adprhl2; AI836109; ARH3; ARHL2_HUMAN; ecto ADP ribosylhydrolase; FLJ20446; OTTMUSP00000009757; Poly(ADP ribose) glycohydrolase ARH3; Poly(ADP-ribose) glycohydrolase ARH3; Protein ADP ribosylarginine hydrolase like protein 2; RP23-113P22.3

Recombinant Human ADP-ribose glycohydrolase ARH3(ADPRS)

Specifications

Immunogen Information

Inquire Recombinant Human ADP-ribose glycohydrolase ARH3(ADPRS) Now

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