Recombinant Human Alanine–tRNA ligase, cytoplasmic (AARS)

Uniprot Id

P49588

Target Species

Human

Target Name

AARS1

Target Full Name

Alanine--tRNA ligase, cytoplasmic

Target Function

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Target Involvement

Charcot-Marie-Tooth disease 2N (CMT2N); Epileptic encephalopathy, early infantile, 29 (EIEE29)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class-II aminoacyl-tRNA synthetase family

Target Synonyms

AARS; AI316495; Alanine tRNA ligase 1, cytoplasmic; Alanine tRNA ligase; Alanine tRNA ligase cytoplasmic; Alanine--tRNA ligase; Alanyl tRNA synthetase; Alanyl tRNA synthetase cytoplasmic; Alanyl-tRNA synthetase; AlaRS; C76919; CMT2N; cytoplasmic; EC 6.1.1.7; MGC37368; Renal carcinoma antigen NY REN 42; Renal carcinoma antigen NY-REN-42; SYAC_HUMAN

Target Background

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.