Recombinant Human Alcohol dehydrogenase 1A (ADH1A)

Uniprot Id

P07327

Target Species

Human

Target Name

ADH1A

Target Full Name

Alcohol dehydrogenase 1A

Target Subcellular Location

Cytoplasm.

Target Protein Families

Zinc-containing alcohol dehydrogenase family

Target Synonyms

ADH alpha subunit; ADH; ADH1; ADH1A; ADH1A_HUMAN; Alcohol dehydrogenase 1 (class I), alpha polypeptide; Alcohol dehydrogenase 1; Alcohol dehydrogenase 1A (class I), alpha polypeptide; Alcohol dehydrogenase 1A; Alcohol dehydrogenase subunit alpha; Aldehyde reductase

Target Background

This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence.