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The recombinant human ALPP protein is encoded by a recombinant DNA that was cloned into the expression vector and then transformed into the Baculovirus that supports the expression of the gene. The recombinant DNA was constructed by fusing the N-terminal 10xHis tag gene to the gene fragment coding for the 117-447aa of the human ALPP protein. After purification, the product is the recombinant human ALPP protein. This recombinant ALPP protein was subjected to the SDS-PAGE determination. Its purity reaches over 85% evaluated by Bandscan software analysis combined with SAS-PAGE. This ALPP protein ran to the molecular weight of about 40 kDa under SDS-PAGE condition.ALPP (or PLAP) protein is an allosteric enzyme encoded by the ALPP gene. ALPP belongs to a multigene family composed of four alkaline phosphatase isoenzymes. ALPP is a membrane-bound glycosylated dimeric enzyme, which is mainly presented on the placental and endometrial tissue. It usually functions as a homodimer. At present, the ALPP protein has been discovered involvement in coronavirus biology, which is relevant for disease process. As identified tumor target, ALPP participates in the progress of tumors like seminoma and ovarian cancer.
The recombinant human ALPP protein is encoded by a recombinant DNA that was cloned into the expression vector and then transformed into the Baculovirus that supports the expression of the gene. The recombinant DNA was constructed by fusing the N-terminal 10xHis tag gene to the gene fragment coding for the 117-447aa of the human ALPP protein. After purification, the product is the recombinant human ALPP protein. This recombinant ALPP protein was subjected to the SDS-PAGE determination. Its purity reaches over 85% evaluated by Bandscan software analysis combined with SAS-PAGE. This ALPP protein ran to the molecular weight of about 40 kDa under SDS-PAGE condition.ALPP (or PLAP) protein is an allosteric enzyme encoded by the ALPP gene. ALPP belongs to a multigene family composed of four alkaline phosphatase isoenzymes. ALPP is a membrane-bound glycosylated dimeric enzyme, which is mainly presented on the placental and endometrial tissue. It usually functions as a homodimer. At present, the ALPP protein has been discovered involvement in coronavirus biology, which is relevant for disease process. As identified tumor target, ALPP participates in the progress of tumors like seminoma and ovarian cancer.
| Cat.No | ACP02225 | Target Name | ALPP |
|---|---|---|---|
| Target Synonyms | ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1 | Form | Liquid or Lyophilized powder |
| Expression System | Baculovirus | Expression Range | 117-447aa |
| Mol Weight | 38.9 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05187 |
|---|
Uniprot Id
P05187
Target Species
Human
Target Name
ALPP
Target Full Name
Alkaline phosphatase, placental type
Target Function
Alkaline phosphatase that can hydrolyze various phosphate compounds.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
Alkaline phosphatase family
Target Tissue Specificity
Detected in placenta (at protein level).
Target Research Area
Tags & Cell Markers
Target Synonyms
ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
Target Background
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.
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