Recombinant Human Angiomotin (AMOT), Truncated

Uniprot Id

Q4VCS5

Target Species

Human

Target Name

AMOT

Target Full Name

Angiomotin

Target Function

Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.

Target Subcellular Location

Cell junction, tight junction. Note=Localized on the cell surface. May act as a transmembrane protein.

Target Protein Families

Angiomotin family

Target Tissue Specificity

Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.

Target Synonyms

AMOT; AMOT_HUMAN; Angiomotin; Angiomotin p130 isoform; KIAA1071

Target Background

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.