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Entire Human Arginase-1/ARG1 cDNA (1-322aa) with an N-terminal GST-tag was expressed in E.coli. The forming protein is the Recombinant full-length Human ARG1 protein. The purity of this protein is greater than 90% as determined by SDS-PAGE. Under reducing conditions, the SDS-PAGE gel showed a molecular weight band of about 62 kDa. This recombinant ARG1 protein may be used for specific antibody production or in the studies of ARG-1-related signal transduction. ARG1 is the last enzyme in the urea cycle and it promotes the conversion of arginine to urea and ornithine. Deficiency of ARG1 causes hyperargininemia/arginase deficiency, an autosomal recessive urea cycle disorder, in which the increased arginine levels result in toxicity. High ARG1 expression has been found in several cancers, such as breast cancer and colorectal cancer. Malgorzata Czystowska-Kuzmicz etc. demonstrated that ARG1 is expressed in ovarian tumors and facilitates ovarian carcinomas (OvCa). The levels of ARG-1 is related to poor prognosis. ARG1 is carried by OvCa-derived small extracellular vesicles (EVs). EVs carrying ARG1 contribute to systemic immune suppression in OvCa patients and suppresses T-cell proliferation in vitro.
Entire Human Arginase-1/ARG1 cDNA (1-322aa) with an N-terminal GST-tag was expressed in E.coli. The forming protein is the Recombinant full-length Human ARG1 protein. The purity of this protein is greater than 90% as determined by SDS-PAGE. Under reducing conditions, the SDS-PAGE gel showed a molecular weight band of about 62 kDa. This recombinant ARG1 protein may be used for specific antibody production or in the studies of ARG-1-related signal transduction.
ARG1 is the last enzyme in the urea cycle and it promotes the conversion of arginine to urea and ornithine. Deficiency of ARG1 causes hyperargininemia/arginase deficiency, an autosomal recessive urea cycle disorder, in which the increased arginine levels result in toxicity. High ARG1 expression has been found in several cancers, such as breast cancer and colorectal cancer. Malgorzata Czystowska-Kuzmicz etc. demonstrated that ARG1 is expressed in ovarian tumors and facilitates ovarian carcinomas (OvCa). The levels of ARG-1 is related to poor prognosis. ARG1 is carried by OvCa-derived small extracellular vesicles (EVs). EVs carrying ARG1 contribute to systemic immune suppression in OvCa patients and suppresses T-cell proliferation in vitro.
| Cat.No | ACP03504 | Target Name | ARG1 |
|---|---|---|---|
| Target Synonyms | A I; Al; ARG 1; arg1; ARGI1_HUMAN; Arginase 1; Arginase liver; Arginase type I; Arginase; liver; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-322aa |
| Mol Weight | 61.7kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05089 |
|---|
Uniprot Id
P05089
Target Species
Human
Target Name
ARG1
Target Full Name
Arginase-1
Target Function
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Target Involvement
Argininemia (ARGIN)
Target Subcellular Location
Cytoplasm. Cytoplasmic granule.
Target Protein Families
Arginase family
Target Tissue Specificity
Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.
Target Research Area
Signal Transduction
Target Synonyms
A I; Al; ARG 1; arg1; ARGI1_HUMAN; Arginase 1; Arginase liver; Arginase type I; Arginase; liver; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase
Target Background
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
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