Recombinant Human Arginine-glutamic acid dipeptide repeats protein (RERE), Truncated

Uniprot Id

Q9P2R6

Target Species

Human

Target Name

RERE

Target Full Name

Arginine-glutamic acid dipeptide repeats protein

Target Function

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.

Target Involvement

Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH)

Target Subcellular Location

Nucleus. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.

Target Tissue Specificity

Widely expressed. Expressed in tumor cell lines.

Target Synonyms

1110033A15Rik; AI414665; ARG; arginine glutamic acid dipeptide (RE) repeats; arginine glutamic acid dipeptide repeats; Arginine glutamic acid dipeptide repeats protein; Arginine-glutamic acid dipeptide repeats protein; ARGININE-GLUTAMIC ACID REPEATS-ENCODING GENE; ARP; ATN1L; Atr2; atrophin 1 like; Atrophin 1 like protein; Atrophin 1 related protein; atrophin 2; atrophin related protein; ATROPHIN-1-ASSOCIATED PROTEIN; Atrophin-1-like protein; Atrophin-1-related protein; atrophin-2; ATROPHIN-RELATED PROTEIN; AW742570; DNB1; FLJ38775; KIAA0458; mKIAA0458; NEDBEH; OTTHUMP00000001701; Rere; RERE_HUMAN

Target Background

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene.