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| Cat.No | ACP07134 | Target Name | KCNJ14 |
|---|---|---|---|
| Target Synonyms | inwardly rectifying subfamily J member 14, KCNJ14; IRK4; ATP-sensitive inward rectifier potassium channel 14; Inward rectifier K(+ channel Kir2.4; IRK-4; Potassium channel | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UNX9 |
|---|
Uniprot Id
Q9UNX9
Target Species
Human
Target Name
KCNJ14
Target Full Name
ATP-sensitive inward rectifier potassium channel 14
Target Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ14 subfamily
Target Tissue Specificity
Expressed preferentially in retina.
Target Synonyms
KCNJ14; IRK4; ATP-sensitive inward rectifier potassium channel 14; Inward rectifier K(+ channel Kir2.4; IRK-4; Potassium channel, inwardly rectifying subfamily J member 14
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