Recombinant Human ATP synthase subunit e, mitochondrial (ATP5I)

Uniprot Id

P56385

Target Species

Human

Target Name

ATP5ME

Target Full Name

ATP synthase subunit e, mitochondrial

Target Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Target Subcellular Location

Mitochondrion. Mitochondrion inner membrane.

Target Protein Families

ATPase e subunit family

Target Synonyms

ATP 5I; ATP 5K; ATP synthase e chain mitochondrial; ATP synthase H+ transporting mitochondrial F0 complex subunit E; ATP synthase subunit e; ATP synthase subunit e mitochondrial; ATP5I; ATP5I_HUMAN; ATP5K; ATPase subunit e; F1F0 ATP synthase murine e subunit; MGC12532; mitochondrial

Target Background

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.