Recombinant Human B-cell CLL/lymphoma 9 protein (BCL9), Truncated

Uniprot Id

O00512

Target Species

Human

Target Name

BCL9

Target Full Name

B-cell CLL/lymphoma 9 protein

Target Function

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity.

Target Involvement

A chromosomal aberration involving BCL9 is found in a patient with precursor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.

Target Subcellular Location

Nucleus.

Target Protein Families

BCL9 family

Target Tissue Specificity

Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood.

Target Synonyms

BCL9B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; Bcl-9; Protein legless homolog

Target Background

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.