Recombinant Human B-cell lymphoma/leukemia 11B (BCL11B), Truncated

Cat.No	ACP05007	Target Name	BCL11B
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	387-823aa	Mol Weight	53.7 kDa
Protein Length	Partial of Isoform 2	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05007

Target Name

BCL11B

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

387-823aa

Mol Weight

53.7 kDa

Protein Length

Partial of Isoform 2

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9C0K0

Background Information

Uniprot Id

Q9C0K0
Target Species

Human
Target Name

BCL11B
Target Full Name

B-cell lymphoma/leukemia 11B
Target Function

Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element. May also function in the P53-signaling pathway.
Target Involvement

Immunodeficiency 49 (IMD49)
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
Target Research Area

Others
Target Synonyms

ATL1 alpha; ATL1; ATL1 beta; ATL1 gamma; ATL1-delta; B cell CLL/lymphoma 11B/T cell receptor delta constant region fusion protein; B cell lymphoma/leukemia 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B; B-cell lymphoma/leukemia 11B; BC11B_HUMAN; BCL-11B; Bcl11b; BCL11B/TRDC fusion; COUP TF interacting protein 2; COUP-TF interacting protein 2; COUP-TF-interacting protein 2; Ctip 2; CTIP-2; CTIP2; hRIT1 alpha; hRit1; Radiation induced tumor suppressor gene 1; Radiation induced tumor suppressor gene 1 protein; Radiation-induced tumor suppressor gene 1 protein; Rit 1; Rit1; zinc finger protein hRit1 alpha; ZNF856B
Target Background

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Recombinant Human B-cell lymphoma/leukemia 11B (BCL11B), Truncated

Specifications

Immunogen Information

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