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| Cat.No | ACP07221 | Target Name | BCL2L10 |
|---|---|---|---|
| Target Synonyms | BCL2L10; BCLB; Bcl-2-like protein 10; Bcl2-L-10; Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HD36 |
|---|
Uniprot Id
Q9HD36
Target Species
Human
Target Name
BCL2L10
Target Full Name
Bcl-2-like protein 10
Target Function
Promotes cell survival by suppressing apoptosis induced by BAX but not BAK. Increases binding of AHCYL1/IRBIT to ITPR1. Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions. Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis.
Target Subcellular Location
Mitochondrion. Nucleus membrane. Endoplasmic reticulum.
Target Protein Families
Bcl-2 family
Target Tissue Specificity
Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.
Target Synonyms
BCL2L10; BCLB; Bcl-2-like protein 10; Bcl2-L-10; Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B
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