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Recombinant Human Beta-defensin 4A (DEFB4A)

ACP03476

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP03476 Target NameDEFB4A
FormLiquid or Lyophilized powderExpression SystemE.coli
Expression Range1-64aaMol Weight31.3kDa
Protein LengthFull lengthPurityGreater than 90% as determined by SDS-PAGE.
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDO15263
Background Information
  • Uniprot Id

    O15263

  • Target Species

    Human

  • Target Name

    DEFB4A

  • Target Full Name

    Defensin beta 4A

  • Target Function

    Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells.

  • Target Subcellular Location

    Secreted.

  • Target Protein Families

    Beta-defensin family, LAP/TAP subfamily

  • Target Tissue Specificity

    Expressed in the skin and respiratory tract.

  • Target Synonyms

    BD 2; BD-2; BD2; beta 2; beta 2 Defensin; Beta defensin 2; Beta defensin 4B; Beta-defensin 2; Beta-defensin 4A; DEF B2; DEF B4; DEFB 102; DEFB 2; DEFB 4; DEFB102; DEFB2; DEFB2; formerly; DEFB4; DEFB4; formerly; DEFB4B; DEFB4P; Defensin; Defensin beta 2; Defensin; beta 4; Defensin; beta 4; pseudogene; Defensin; beta 4A; Defensin; beta 4B; Defensin; beta; 2; formerly; Defensin; beta; 4; formerly; DFB4A_HUMAN; HBD 2; hBD-2; HBD2; mBD-2; SAP 1; SAP1; Skin antimicrobial peptide 1; Skin-antimicrobial peptide 1

  • Target Background

    Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation.

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