Recombinant Human Biglycan (BGN)

Uniprot Id

P21810

Target Species

Human

Target Name

BGN

Target Full Name

Biglycan

Target Function

May be involved in collagen fiber assembly.

Target Involvement

Meester-Loeys syndrome (MRLS); Spondyloepimetaphyseal dysplasia, X-linked (SEMDX)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Small leucine-rich proteoglycan (SLRP) family, SLRP class I subfamily

Target Tissue Specificity

Found in several connective tissues, especially in articular cartilages.

Target Research Area

Signal Transduction

Target Synonyms

BGN; Biglycan; Biglycan proteoglycan; Bone/cartilage proteoglycan I; Dermatan sulphate proteoglycan I; DSPG1 ; PG S1; PG-S1; PGI; PGS1_HUMAN; SEMDX; SLRR1A; Small leucine rich protein 1A

Target Background

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication.