Recombinant Human Bis (5′-nucleosyl)-tetraphosphatase [asymmetrical] (NUDT2)

Uniprot Id

P50583

Target Species

Human

Target Name

NUDT2

Target Full Name

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Target Function

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.

Target Protein Families

Nudix hydrolase family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

2310051L06Rik; 5''''-P1; AA939917; Ap4A hydrolase 1; Ap4A hydrolase; AP4A_HUMAN; Ap4Aase; APAH 1; APAH1; Bis(5' nucleosyl) tetraphosphatase [asymmetrical]; Bis(5''-nucleosyl)-tetraphosphatase [asymmetrical]; Diadenosine 5''; Diadenosine 5',5''' P1,P4 tetraphosphate asymmetrical hydrolase; Diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase; EC 3.6.1.17; MGC10404; Nucleoside diphosphate linked moiety X motif 2; Nucleoside diphosphate-linked moiety X motif 2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; Nudix motif 2; Nudix-type motif 2; NUDT 2; NUDT2; OTTHUMP00000021256; OTTHUMP00000021257; OTTHUMP00000021258; OTTHUMP00000021259; P4-tetraphosphate asymmetrical hydrolase

Target Background

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified.